Short

A 2 year old girl is brought in for evaluation of short stature. Her height centiles have been inadequate from 9 months of age.

She was born at term with a weight of 3.35 kg and a length of 45 cm, with no perinatal or postnatal complications. Her medical history is unremarkable, and she is developmentally normal except for a mild delay in gross motor milestones. Her parents are first cousins, and are of normal heights.

She was investigated for short stature 3 months ago; her diet was found to be adequate, while her hematological indices and renal, thyroid, and liver function tests were normal. However, her bone age was found to be only 12 months.

Select Relevant Investigations
Karyotyping

Performed

Her karyotype is 46,XX
Skeletal Survey

Performed

No abnormalities detected
Pituitary Function Tests

Performed

Growth Hormone: 50 ng/ml (0-20)
All other pituitary hormone levels are within normal parameters.
IGF-I levels

Performed

IGF-I: 15 ng/ml (49-289)

Select Relevant Management
Recombinant Growth Hormone
Watchful Waiting
Recombinant IGF
Implantable Limb Lengthening