Early

A 10 year old caucasian boy is referred for further management after his fasting plasma glucose is found to be 132 mg/dl.

During the preceding year, he had experienced several episodes of increased urination, thirst and appetite.

His mother and maternal grandfather were diagnosed with diabetes at the ages of 27 and 30 respectively.

Select Relevant Investigations
Endocrine panel

Performed

Low dose dexamethasone suppression test: negative
Free-T3, Free-T4, S. TSH: Within normal parameters
Diabetes mellitus autoantibody panel

Performed

No autoantibodies (ICA, IAA or GAD) are detected.
C peptide level

Performed

The C-peptide level is 1.50 ng/ml (normal: 0.51 - 2.72)
Genetic testing

Performed

A heterozygous missense mutation is detected in the glucokinase gene

Select Relevant Management
Insulin stat
Oral hypoglycemics stat
Screen family members
Dietary measures